Cyclosporine A alleviates severe anaemia associated with refractory large granular lymphocytic leukaemia and chronic natural killer cell lymphocytosis

摘要: Large granular lymphocytic (LGL) leukaemia and chronic natural killer cell lymphocytosis (CNKL) are indolent disorders often associated with neutropenia constitutional symptoms. Severe anaemia occurs in about 20% of patients is currently treated corticosteroids followed by oral cyclophosphamide non-responders. 30% fail initial measures, salvage therapy inadequate. We describe three transfusion-dependent (two T-LGL leukaemia, one CNKL) refractory to corticosteroids, cyclophosphamide, case fludarabine. Cyclosporine A (CSA) initiation resulted prompt transfusion-independence was well tolerated all patients, making it an attractive alternative for this disorder.