Cellular alterations of mucosal integrity by ribotoxins: Mechanistic implications of environmentally-linked epithelial inflammatory diseases

摘要: Specific ribosome-directed stressors have the capacity to damage 28S ribosomal RNA by interfering with its functioning during gene translation. This can lead what has been called ribotoxic stress responses that are closely associated various disease processes including epithelial inflammation in humans and domestic animals. Since primary toxic actions of most agents generally recognized be functional inhibition global protein synthesis, highly dividing tissues epithelia susceptible targets insult. In present study, mucosal barrier acute chronic exposure ribosome-inactivating were reviewed experimental models. Specifically, focus this review will on regulation mucosa-associated microbiota, pro-inflammatory insult, integrity. The aims at characterizing mechanistic evidence stress-induced cellular their implication as critical etiological factors diseases, particular inflammatory disease.