Quantitative Assessment of Common Genetic Variants on Chromosome 5p12 and Hormone Receptor Status with Breast Cancer Risk
作者： Yanmin Yu , Zenggan Chen , Hong Wang , Yan Zhang
DOI: 10.1371/JOURNAL.PONE.0072154
关键词:
摘要: Several genome-wide association studies on breast cancer (BC) have reported similar findings of a new susceptibility locus, 5p12. After that, number that the rs10941679, rs4415084, and rs981782 polymorphism in chromosome 5p12 has been implicated BC risk. However, yielded contradictory results. To derive more precise estimation relationship, meta-analysis 131,983 cases 200,314 controls from 24 published case–control was performed. Overall, significantly elevated risk associated with allele when all were pooled into meta-analysis. In subgroup analysis by ethnicity, increased risks found for rs10941679 rs4415084 among Caucasians East Asians, while no significant associations observed two polymorphisms African other ethnic populations. For 5p12-rs981782, only detected Caucasians. addition, we confer risk, exclusively estrogen receptor (ER)-positive tumors per-allele OR 1.16 (95% CI: 1.11–1.21; P<10−5) 1.14 1.09–1.19; respectively. Ethnicity identified as potential source between-study heterogeneity. conclusion, this demonstrated common variations are factor susceptibility, but these vary different
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