Hepatocyte-specific receptor-mediated endocytosis-type compositions

摘要: A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability certain cells to recognize and internalize macromolecules, including MR present invention, via a process which substantially involves receptor mediated endocytosis. The RME-type herein comprised biodegradable superparamagnetic metal oxides associated with variety macromolecular species, but not limited to, serum proteins, hormones, asialoglycoproteins, galactose-terminal polysaccharides, arabinogalactan, or conjugates these molecules other polymeric substances such as poly(organosilane) dextran. One advantages that they may be selectively directed those bear receptors for particular macromolecule ligand capable undergoing An agent prepared from iron oxide asialofetuin, more preferably example, localized hepatocytes liver no significant accumulation spleen. experiment can carried out shortly after administration subject invention thus provide method obtaining an enhanced image, well valuable information regarding functional metabolic state organ tissue under examination. Preparative methods, data, time function images further provided.