The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transfer
作者： Hillary S. Klonoff-Cohen , Loki Natarajan
DOI: 10.1016/J.AJOG.2004.01.035
关键词:
摘要: Abstract Objective This study was undertaken to determine effects of male aging on sperm parameters, fertilization, pregnancy, and live birth rates among in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT) couples. The impact female age also investigated. Study design Prospective made up 221 IVF GIFT Results Pregnancy declined as the subjects aged. Each additional year paternal associated with 11% increased odds ( P =.007) not achieving a 12% =.01) having successful birth. For first-time IVF/GIFT recipients, each 5% whereas for repeaters it 40% =.01). Advancing maternal decreased numbers oocytes retrieved fertilized. Women 40 years older compared younger than 35 had greater 4-fold risk becoming pregnant, 20-fold Conclusion (and maternal) deleterious effect outcomes.
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