An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events.

摘要: The inflammation process represents of a dynamic series phenomena that manifest themselves with an intense vascular reaction. Neuroinflammation is reply from the central nervous system (CNS) and peripheral (PNS) to changed homeostasis. There are two cell systems mediate this process: glia CNS lymphocites, monocytes, macrophages hematopoietic system. In both systems, neuroinflammation plays important role in pathogenesis neurodegenerative diseases, such as Parkinson’s Alzheimer’s neuropsychiatric illnesses, depression autism spectrum disorders. resolution allows for inflamed tissues return players represented by lipid mediators. Among naturally occurring signaling molecules, prominent played N-acylethanolamines, namely N-arachidonoylethanolamine its congener N-palmitoylethanolamine, which also named palmitoylethanolamide or PEA. PEA possesses powerful neuroprotective anti-inflammatory power but has no antioxidant effects per se. For reason, co-ultramicronization flavonoid luteolin more efficacious than either molecule alone. Inhibiting modulating enzymatic breakdown complementary therapeutic approach treating neuroinflammation. aim review discuss ultramicronized co-ultramicronized several neurological diseases using preclinical clinical approaches.