Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells

作者: Ryutaro Mori , Kazuhiro Yoshida , Toshiyuki Tanahashi , Kazunori Yawata , Junko Kato

DOI: 10.1007/S10120-012-0191-0

关键词:

摘要: Background Oxaliplatin is effective against many types of cancer, and the combination 5-fluorouracil (5FU) oxaliplatin synergistically gastric as well colon cancer. The FANCJ protein one Fanconi anemia (FA) gene products, its interaction with tumor suppressor BRCA1 required for DNA double-strand break (DSB) repair. also functions in interstrand crosslinks (ICLs) repair by linking to mismatch complex MLH1-PMS2 (MutLα). While causes ICLs, 5FU considered cause DSBs. Therefore, we investigated importance synergistic effects MKN45 cancer cells derived 5FU-resistant cell line, MKN45/F2R.

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