Red blood cell copper, zinc superoxide dismutase activity is higher in Alzheimer's disease and is decreased by D-penicillamine.
作者： Luisa Rossi , Rosanna Squitti , Patrizio Pasqualetti , Eliana Marchese , Emanuele Cassetta
DOI: 10.1016/S0304-3940(02)00599-2
关键词:
摘要: Copper, zinc superoxide dismutase (Cu, Zn SOD) activity was measured in red blood cells (RBC) of 32 patients affected by Alzheimer's disease (AD), eight other AD treated with the copper-chelating agent D-penicillamine, 13 first-degree relatives and 22 controls. All enrolled our study showed a higher level Cu, SOD early disease. No correlation between apolipoprotein E genotype found patients. D-penicillamine treatment for 24 weeks lowered enzyme even below control value. These results support hypothesis that RBC can be an diagnostic peripheral marker this sensor to monitor treatments drugs.
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Lawrence M. Sayre, George Perry, Peggy L. R. Harris, Yahua Liu, Kathryn A. Schubert, Mark A. Smith, In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. Journal of Neurochemistry. ,vol. 74, pp. 270- 279 ,(2001) , 10.1046/J.1471-4159.2000.0740270.X
M.E De Leo, S Borrello, M Passantino, B Palazzotti, A Mordente, A Daniele, V Filippini, T Galeotti, C Masullo, Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease Neuroscience Letters. ,vol. 250, pp. 173- 176 ,(1998) , 10.1016/S0304-3940(98)00469-8
R. Squitti, P. M. Rossini, E. Cassetta, F. Moffa, P. Pasqualetti, M. Cortesi, A. Colloca, L. Rossi, A. Finazzi-Agro′, d
-penicillamine reduces serum oxidative stress in Alzheimer’s disease patients European Journal of Clinical Investigation. ,vol. 32, pp. 51- 59 ,(2002) , 10.1046/J.1365-2362.2002.00933.X
Mark A. Smith, Catherine A. Rottkamp, Akihiko Nunomura, Arun K. Raina, George Perry, Oxidative stress in Alzheimer's disease. Biochimica et Biophysica Acta. ,vol. 1502, pp. 139- 144 ,(2000) , 10.1016/S0925-4439(00)00040-5
Robert D. Moir, Craig S. Atwood, Donna M. Romano, Maxwell H. Laurans, Xudong Huang, Ashley I. Bush, Jonathan D. Smith, Rudolph E. Tanzi, Differential Effects of Apolipoprotein E Isoforms on Metal-Induced Aggregation of Aβ Using Physiological Concentrations† Biochemistry. ,vol. 38, pp. 4595- 4603 ,(1999) , 10.1021/BI982437D
Rachel Perrin, Serge Briançon, Claude Jeandel, Yves Artur, Alain Minn, Francis Penin, Gérard Siest, Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study. Gerontology. ,vol. 36, pp. 306- 313 ,(1990) , 10.1159/000213215
González, Martín, Cacho, Breñas, Arroyo, García-Berrocal, Navajo, González-Buitrago, Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers. European Journal of Clinical Investigation. ,vol. 29, pp. 637- 642 ,(1999) , 10.1046/J.1365-2362.1999.00471.X
Y. Ihara, T. Hayabara, K. Sasaki, R. Kawada, Y. Nakashima, S. Kuroda, Relationship between oxidative stress and apoE phenotype in Alzheimer's disease Acta Neurologica Scandinavica. ,vol. 102, pp. 346- 349 ,(2000) , 10.1034/J.1600-0404.2000.102006346.X
Repetto, Reides, Evelson, Kohan, De Lustig, Llesuy, Peripheral markers of oxidative stress in probable Alzheimer patients. European Journal of Clinical Investigation. ,vol. 29, pp. 643- 649 ,(1999) , 10.1046/J.1365-2362.1999.00506.X
Craig S. Atwood, Robert D. Moir, Xudong Huang, Richard C. Scarpa, N. Michael E. Bacarra, Donna M. Romano, Mariana A. Hartshorn, Rudolph E. Tanzi, Ashley I. Bush, Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis Journal of Biological Chemistry. ,vol. 273, pp. 12817- 12826 ,(1998) , 10.1074/JBC.273.21.12817