Bifidobacterium animalis subsp. lactis in prevention of common infections in healthy children attending day care centers – Randomized, double blind, placebo-controlled study

摘要: Summary Background & aims The aim of our study was to investigate the role Bifidobacterium animalis subsp . lactis (BB-12 ® ) in prevention common (gastrointestinal and respiratory) infections healthy children who attend day care centers. Methods We conducted a randomized, double-blind, placebo-controlled trial 210 They were randomly allocated receive placebo (Placebo group, n = 106) or BB-12 at dose 10 9  colony-forming units (CFU) (Intervention n = 104) during 3-month intervention period. Results Intention treat analysis used. There overall 99 Placebo group 97 Intervention (incidence rate ratio = 1.0014, p = 0.992, Poisson regression model). Overall 65 (61.3%) 67 (64.4%) had (p = 0.642). Mean number per child 0.93 (range 0–3) (p = 0.898). no difference secondary (duration symptoms, with gastrointestinal respiratory tract infections, absence from center due use antibiotics) exploratory (type infection) endpoints between groups. Conclusion performed show that has effect on