Structural Studies of the Growth Hormone Receptor by Affinity Labeling
作者： David B. Donner , Kazuyo Yamada , Kenneth E. Lipson , Andrea Dorato
DOI: 10.1007/978-1-4615-7201-5_37
关键词:
摘要: Detailed information of receptor structure can be obtained by covalently coupling radioactively labeled peptide hormones to membrane binding sites with chemical cross-linking reagents.(1) Disuccinimidyl esters have been particularly useful for such affinity labeling as they react rapidly free amino groups under physiological conditions, thereby minimizing distortion structure.(2) Using reagents, the receptors insulin(3,4) and insulinlike growth factors(5,6) characterized.
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