Reduced-intensity conditioning for hematopoietic cell transplantation of chronic granulomatous disease.

摘要: Hematopoietic cell transplantation (HCT) is the only available curative therapy for chronic granulomatous disease (CGD), but its use limited by transplant-related mortality (TRM) in patients who often come to transplant with existing infections or organ dysfunction. Reduction intensity of preparative regimen mitigates these risks, increases potential mixed donor-recipient chimerism (MC) that may progress graft loss. Recently a busulfan-based reduced-intensity conditioning (RIC) has been described excellent survival and little MC. We report our experience similar RIC at institution, demonstrating problems donor Pediatr Blood Cancer 2015;62:359-361. © 2014 Wiley Periodicals, Inc.