Vascular calcification and renal osteodystrophy relationship in chronic kidney disease.

摘要: Cardiovascular disease and stroke account for 60-70% of all deaths in patients with end-stage renal (ESRD), at a risk that is 10-20-fold the age- sex-matched general population. There also increased coronary artery calcification cardiovascular mortality chronic kidney (CKD) dialysis compared Bone similarly abnormal CKD. an incidence low bone mass fractures Furthermore, hip fracture patient associated doubling observed nondialysis fracture. These two problems may be linked, as cross-sectional studies have demonstrated inverse relationship between osteoporosis population ESRD patients. In vitro ex vivo, there clear evidence vascular active cell-mediated process, made worse by disorders mineral metabolism. Many factors known to CKD can directly increase vitro. addition, CKD, are many mechanisms which adversely affect including remodelling, altered secretion parathyroid hormone (PTH), hyperphosphatemia, hypercalcaemia, use calcium based binders, excessive vitamin D therapy. The coexistence represent double threat well being