A year's comparison of treatment of patients with parkinson's disease with levodopa combined with carbidopa versus treatment with levodopa alone.

摘要: Abstract Forty patients were treated with levodopa combined the selective extracerebral dopa-decarboxylase inhibitor carbidopa (MK 486). Once stabilised on optimum dosage a fixed dose of (50 mg. four times day), they randomly allocated either to continue this treatment for year or switch plus placebo year. The clinical response all was rapid, significant reduction in total disability within 2 weeks. Optimum obtained 4-20 weeks, and greater part improvement seen that time, contrast slow increase delayed appearance benefit alone. After initial period treatment, fared better over trial than those They had much less nausea vomiting slightly response, although showed more abnormal involuntary movements, three developed "on/off" effect. benefits indicate is now therapy choice Parkinson's disease who require levodopa.