Resin-based dental materials containing 3-aminopropyltriethoxysilane modified halloysite-clay nanotubes for extended drug delivery.

摘要: Abstract Objective To synthesize and characterize a novel resin-based dental material containing 3-aminopropyltriethoxysilane (APTES) surface-modified halloysite-clay nanotubes (HNTs) for long-term delivery of guest molecules. Methods The optimal concentrations HNT (10, 15, 20 wt.%) silane (0, 2, 4 vol.%sil) to be incorporated into the materials were determined (15 wt.%HNT, after assessment mechanical properties (DC%, degree conversion; FS, flexural strength; FM, modulus; UTS, ultimate tensile strength). HNTsil-powder was loaded with chlorhexidine (CHX) evaluate effect silanization on drug release. Resin-discs prepared following groups: RES (resin), (resin+15 wt.%HNT), HNTsil wt.%HNT silanized), HNT-CHX chlorhexidine), HNTsil-CHX wt.%HNTsil-CHX), 0.2 vol.%CHX (resin+0.2 solution). Specimens stored in water 1, 3, 5, 10, 15 days at 37 °C. Aliquots from each time point final 15-day specimens evaluated zone inhibition (ZOI) against Streptococcus mutans. CHX release analyzed using spectrophotometry absorbance 300 nm. Data statistically (α = 0.05). Results All presented similar DC%. Reduced FS but increased FM detected wt.%HNT–4%APTES. Groups wt.% with/without APTES higher values UTS. Agar diffusion data indicates that had greater ZOI than all other groups over days. highest day 1 every after. Significance Silanization followed by encapsulation is promising technique