作者: Barry J. Thompson
DOI: 10.1007/978-3-319-14463-4_14
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摘要: Previous chapters have introduced the core determinants of apicobasal polarity in different cell types. This chapter will examine how these become localised to particular membrane domains Drosophila. In some types, such as neuroblasts, does not rely on transmembrane proteins or trafficking. contrast, epithelial involves several key proteins, Crumbs and E-cadherin, their distribution depends critically exocytic endocytic machinery. addition, certain types cells secrete an apical extracellular matrix a basement matrix, processes that must involve polarised delivery components. Disruption trafficking can therefore lead loss tumour-like phenotypes