Genetics of early growth traits.
作者： Diana L Cousminer , Rachel M Freathy
DOI: 10.1093/HMG/DDAA149
关键词:
摘要: In recent years, genome-wide association studies have shed light on the genetics of early growth and its links with later-life health outcomes. Large-scale datasets meta-analyses, combined recently developed analytical methods, enabled dissection maternal fetal genetic contributions to variation in birth weight. Additionally, longitudinal approaches shown differences between infant, childhood adult adiposity. contrast, height loci strong associations body length height. Early growth-associated provide useful tools for causal analyses: Mendelian randomization (MR) provided evidence that BMI are causally related a number We advise caution design interpretation MR weight investigating effects cardiometabolic disease because is only crude indicator growth, choice instrument (maternal or fetal) will greatly influence results. Most date centered European-ancestry participants outcomes measured at single time-point, so key priorities future aggregation large samples diverse ancestries trajectories.
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Andrew T. Hattersley, Frances Beards, Elizabeth Ballantyne, Maggie Appleton, Rod Harvey, Sian Ellard, Mutations in the glucokinase gene of the fetus result in reduced birth weight Nature Genetics. ,vol. 19, pp. 268- 270 ,(1998) , 10.1038/953
Gosia Trynka, Harm-Jan Westra, Kamil Slowikowski, Xinli Hu, Han Xu, Barbara E. Stranger, Robert J. Klein, Buhm Han, Soumya Raychaudhuri, Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci. American Journal of Human Genetics. ,vol. 97, pp. 139- 152 ,(2015) , 10.1016/J.AJHG.2015.05.016
Serena Sanna, Anne U Jackson, Ramaiah Nagaraja, Cristen J Willer, Wei-Min Chen, Lori L Bonnycastle, Haiqing Shen, Nicholas Timpson, Guillaume Lettre, Gianluca Usala, Peter S Chines, Heather M Stringham, Laura J Scott, Mariano Dei, Sandra Lai, Giuseppe Albai, Laura Crisponi, Silvia Naitza, Kimberly F Doheny, Elizabeth W Pugh, Yoav Ben-Shlomo, Shah Ebrahim, Debbie A Lawlor, Richard N Bergman, Richard M Watanabe, Manuela Uda, Jaakko Tuomilehto, Josef Coresh, Joel N Hirschhorn, Alan R Shuldiner, David Schlessinger, Francis S Collins, George Davey Smith, Eric Boerwinkle, Antonio Cao, Michael Boehnke, Gonçalo R Abecasis, Karen L Mohlke, Common variants in the GDF5-UQCC region are associated with variation in human height Nature Genetics. ,vol. 40, pp. 198- 203 ,(2008) , 10.1038/NG.74
Ashraf Soliman, VincenzoDe Sanctis, Rania Elalaily, Said Bedair, Advances in pubertal growth and factors influencing it: Can we increase pubertal growth? Indian Journal of Endocrinology and Metabolism. ,vol. 18, pp. 53- ,(2014) , 10.4103/2230-8210.145075
Louise N. Reynard, Catherine Bui, Catherine M. Syddall, John Loughlin, CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383 Human Genetics. ,vol. 133, pp. 1059- 1073 ,(2014) , 10.1007/S00439-014-1447-Z
Y. Kelly, L. Panico, M. Bartley, M. Marmot, J. Nazroo, A. Sacker, Why does birthweight vary among ethnic groups in the UK? Findings from the Millennium Cohort Study. Journal of Public Health. ,vol. 31, pp. 131- 137 ,(2008) , 10.1093/PUBMED/FDN057
John A. Curtin, Ronny Myhre, Ville Huikari, Raimo Joro, Marjan Kerkhof, Nicole M. Warrington, Niina Pitkänen, Ioanna Ntalla, Momoko Horikoshi, Riitta Veijola, Rachel M. Freathy, Yik-Ying Teo, Sheila J. Barton, David M. Evans, John P. Kemp, Beate St Pourcain, Susan M. Ring, George Davey Smith, Anna Bergström, Inger Kull, Hakon Hakonarson, Frank D. Mentch, Hans Bisgaard, Bo Chawes, Jakob Stokholm, Johannes Waage, Patrick Eriksen, Astrid Sevelsted, Mads Melbye, Cornelia M. van Duijn, Carolina Medina-Gomez, Albert Hofman, Johan C. de Jongste, H. Rob Taal, André G. Uitterlinden, Loren L. Armstrong, Johan Eriksson, Aarno Palotie, Mariona Bustamante, Xavier Estivill, Juan R. Gonzalez, Sabrina Llop, Wieland Kiess, Anubha Mahajan, Claudia Flexeder, Carla M.T. Tiesler, Clare S. Murray, Angela Simpson, Per Magnus, Verena Sengpiel, Anna-Liisa Hartikainen, Sirkka Keinanen-Kiukaanniemi, Alexandra Lewin, Alexessander Da Silva Couto Alves, Alexandra I. Blakemore, Jessica L. Buxton, Marika Kaakinen, Alina Rodriguez, Sylvain Sebert, Marja Vaarasmaki, Timo Lakka, Virpi Lindi, Ulrike Gehring, Dirkje S. Postma, Wei Ang, John P. Newnham, Leo-Pekka Lyytikäinen, Katja Pahkala, Olli T. Raitakari, Kalliope Panoutsopoulou, Eleftheria Zeggini, Dorret I. Boomsma, Maria Groen-Blokhuis, Jorma Ilonen, Lude Franke, Joel N. Hirschhorn, Tune H. Pers, Liming Liang, Jinyan Huang, Berthold Hocher, Mikael Knip, Seang-Mei Saw, John W. Holloway, Erik Melén, Struan F.A. Grant, Bjarke Feenstra, William L. Lowe, Elisabeth Widén, Elena Sergeyev, Harald Grallert, Adnan Custovic, Bo Jacobsson, Marjo-Riitta Jarvelin, Mustafa Atalay, Gerard H. Koppelman, Craig E. Pennell, Harri Niinikoski, George V. Dedoussis, Mark I. Mccarthy, Timothy M. Frayling, Jordi Sunyer, Nicholas J. Timpson, Fernando Rivadeneira, Klaus Bønnelykke, Vincent W.V. Jaddoe, , , Ralf J.P. van der Valk, Eskil Kreiner-Møller, Marjolein N. Kooijman, Mònica Guxens, Evangelia Stergiakouli, Annika Sääf, Jonathan P. Bradfield, Frank Geller, M. Geoffrey Hayes, Diana L. Cousminer, Antje Körner, Elisabeth Thiering, A novel common variant in DCST2 is associated with length in early life and height in adulthood Human Molecular Genetics. ,vol. 24, pp. 1155- 1168 ,(2015) , 10.1093/HMG/DDU510
Louise N. Reynard, Catherine Bui, Elizabeth G. Canty-Laird, David A. Young, John Loughlin, Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation Human Molecular Genetics. ,vol. 20, pp. 3450- 3460 ,(2011) , 10.1093/HMG/DDR253
George Davey Smith, Shah Ebrahim, None, ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? International Journal of Epidemiology. ,vol. 32, pp. 1- 22 ,(2003) , 10.1093/IJE/DYG070
Yoshinari Miyamoto, Akihiko Mabuchi, Dongquan Shi, Toshikazu Kubo, Yoshio Takatori, Susumu Saito, Mikihiro Fujioka, Akihiro Sudo, Atsumasa Uchida, Seizo Yamamoto, Koichi Ozaki, Masaharu Takigawa, Toshihiro Tanaka, Yusuke Nakamura, Qing Jiang, Shiro Ikegawa, A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis Nature Genetics. ,vol. 39, pp. 529- 533 ,(2007) , 10.1038/2005