Synthesis and biological activities of 2,3-dihydro-1,3,4-oxadiazole compounds and its derivatives as potential activator of ryanodine receptors.
作者： Yunyun Zhou , Baolei Wang , Fengjuan Di , Lixia Xiong , Na Yang
DOI: 10.1016/J.BMCL.2014.03.077
关键词:
摘要: Abstract A series of novel 2,3-dihydro-1,3,4-oxadiazoles containing N-pyridylpyrazole carboxamides moieties were obtained by applying a new synthetic route. Their insecticidal tests against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that most the compounds showed moderate to excellent activities at testing concentrations. In particular, compound 6a 40% larvicidal 1 mg/L, while 7a was 100% 0.01 mg/L. Calcium imaging results demonstrated 6a, 6d stimulated transient elevation in [Ca2+]i absence external calcium after central neurons dye loading with fluo-3 AM, implying these potential activators ligand-gated channel on endoplasmic reticulum.
sci-hub.se 参考文章(22)
Xing-Hai Liu, Cheng-Xia Tan, Jian-Quan Weng, Hui-Jun Liu, (E)-(4-Bromobenzylidene)amino cyclopropanecarboxylate Acta Crystallographica Section E Structure Reports Online. ,vol. 68, pp. o493- o493 ,(2012) , 10.1107/S1600536812002048
YUXIN LI, MINGZHEN MAO, YIMING LI, LIXIA XIONG, ZHENGMING LI, JUNYING XU, Modulations of high-voltage activated Ca2+ channels in the central neurones of Spodoptera exigua by chlorantraniliprole Physiological Entomology. ,vol. 36, pp. 230- 234 ,(2011) , 10.1111/J.1365-3032.2011.00788.X
Cheng-Xia Tan, Jian-Quan Weng, Zheng-Xiao Liu, Xing-Hai Liu, Wei-Guang Zhao, Synthesis, Crystal Structure, and Fungicidal Activity of a Novel 1,2,3-Thiadiazole Compound Phosphorus Sulfur and Silicon and The Related Elements. ,vol. 187, pp. 990- 996 ,(2012) , 10.1080/10426507.2012.664219
Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li, Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea. Journal of Agricultural and Food Chemistry. ,vol. 60, pp. 7565- 7572 ,(2012) , 10.1021/JF302446C
Yuhao Li, Hongjun Zhu, Kai Chen, Rui Liu, Abdalla Khallaf, Xiangning Zhang, Jueping Ni, Synthesis, insecticidal activity, and structure-activity relationship (SAR) of anthranilic diamides analogs containing oxadiazole rings. Organic and Biomolecular Chemistry. ,vol. 11, pp. 3979- 3988 ,(2013) , 10.1039/C3OB40345A
Hui-Jun Liu, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, 1-Cyano-N-(2,4,5-trichloro-phen-yl)cyclo-propane-1-carboxamide. Acta Crystallographica Section E-structure Reports Online. ,vol. 67, ,(2011) , 10.1107/S1600536811026225
Shaoyong Ke, Zhong Li, Xuhong Qian, 1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: synthesis, evaluation, and role of urea moiety. Bioorganic & Medicinal Chemistry. ,vol. 16, pp. 7565- 7572 ,(2008) , 10.1016/J.BMC.2008.07.026
David B. Sattelle, Daniel Cordova, Timothy R. Cheek, Insect ryanodine receptors: molecular targets for novel pest control chemicals Invertebrate Neuroscience. ,vol. 8, pp. 107- 119 ,(2008) , 10.1007/S10158-008-0076-4
Mina Behrouzi-Fardmoghadam, Fatemeh Poorrajab, Sussan Kaboudanian Ardestani, Saeed Emami, Abbas Shafiee, Alireza Foroumadi, Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines. Bioorganic & Medicinal Chemistry. ,vol. 16, pp. 4509- 4515 ,(2008) , 10.1016/J.BMC.2008.02.052
Yunyun Zhou, Qi Feng, Fengjuan Di, Qiaoxiao Liu, Duoyi Wang, Youwei Chen, Lixia Xiong, Haibin Song, Yuxin Li, Zhengming Li, Synthesis and insecticidal activities of 2,3-dihydroquinazolin-4(1H)-one derivatives targeting calcium channel Bioorganic & Medicinal Chemistry. ,vol. 21, pp. 4968- 4975 ,(2013) , 10.1016/J.BMC.2013.06.060