Polyglutamine-containing aggregates in neuronal intranuclear inclusion disease

摘要: of NIID may be caused by a CAG repeat expansion in an unknown gene leading to the intranuclear aggregation polyglutamine containing proteins. Possible genetic heterogeneity within this phenotype is suggested fact that inclusions four other cases were 1C2 negative (data not shown). Alternatively, finding reflect difficulty staining with even after vigorous antigen retrieval. Identification underlying mutation will resolve issue, and provide further insight into mechanism neurodegeneration disorder.