Cloning of Genes for N-linked Oligosaccharide Synthesis in Endoplasmic Reticulum

摘要: A congenital disorder of glycosylation syndrome (CDGS) is an autosomal recessive on protein N-glycosylation. The mutated genes causing CDGS are found in N-linked oligosaccharide synthesis gene the endoplasmic reticulum (ER) (Chantret et al. 2003; Frank 2004). N-glycosylation pathway ER almost same any eukaryotic cells from yeast to human. Since most and corresponding mutant strains have been isolated yeast, we cloned characterized human by phenotypic complementation cells.