Trophic stimulation of steroidogenesis: in search of the elusive trigger.

摘要: Publisher Summary This chapter describes trophic stimulation of steroidogenesis. It discusses the source mitochondrial cholesterol and mechanism transport. The fact that side-chain cleavage system is confined to mitochondria made energy for a subject considerable interest. has been found in beef adrenal, reaction can use reversed electron transport transhydrogenation as reducing equivalents form nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) reaction. Mitochondrial malic enzyme—suggested NADPH 11β-hydroxylation—cannot account greater consumption required cleavage. This information does not reveal how adrenocorticotropic hormone (ACTH) regulates rate production pregnenolone. There no evidence suggests ACTH or cyclic adenosine monophosphate increases by adrenal. Purification enzyme from adrenal reveals important properties enzyme, such stoichiometry reaction, involvement heme 20,22 bond, aggregation an active composed 16 subunits. However action still unknown.