Human papillomavirus detection by the hybrid capture II assay: a reliable test to select women with normal cervical smears at risk for developing cervical lesions.

摘要: The reliability of the Hybrid Capture II (HC-II; Digene, Silver Spring, MD, U.S.A.) assay was tested in detecting 18 human Papillomavirus (HPV) types for screening cervical lesions. Cytology, HPV testing, colposcopy, and biopsy were used to monitor 204 women with normal smears at first entry. median follow-up 15 months (range, 4-27 months). primary endpoint clinical progression defined as presence a intraepithelial lesion biopsy. In patient population HPV-infected women, 81 (39.7%) had persistent infection two or three examinations final histologic diagnosis 14 high-grade 13 low-grade squamous lesions (SIL) within 4 22 months. Women regressive did not develop any during same period. evaluation viral load high-risk by HC-II represent sensitive approach predict persistence apparition Thus, detected represents reliable tool select populations risk development