Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells.
作者： Dominique L. Ouellet , Patrick Provost
DOI: 10.1007/978-1-60761-588-0_3
关键词:
摘要: Within the past few years, microRNAs (miRNAs) and other noncoding RNAs (ncRNAs) have emerged as elements with critically high importance in posttranscriptional control of cellular and, more recently, viral processes. Endogenously produced by a component miRNA-guided RNA silencing machinery known Dicer, miRNAs are to messenger (mRNA) translation through recognition specific binding sites usually located their 3' untranslated region. Recent evidences indicate that host miRNA pathway may represent an adapted antiviral defense mechanism can act either direct miRNA-mediated modulation gene expression or inactivation structured species protein components such Dicer. This latter process, however, is double-edge sword, it yield exerting regulatory properties on both mRNAs. Our knowledge interaction between viruses machineries, how this influences course infection, becoming increasingly complex. chapter aims summarize our current about miRNAs/ncRNAs targets, well modulated upon infection.
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