An Outbreak of Nosocomial Infection Due to Multiply Resistant Serratia marcescens: Evidence of Interhospital Spread

摘要: Interhospital spread appeared to be responsible for a large epidemic of infections due strain Serratia marcescens that was resistant all currently available parenteral antibiotics. Between April 1, 1973 and January 1975, 210 patients in four geographically separate hospitals Nashville, Tennessee, were infected with the strain; 21 bacteremic eight died. Catheter-associated urinary tract infection accounted majority isolates, broad-spectrum antibiotic exposure promote acquisition strain. The serotype (O1:H7) phage type (186) organism identical hospitals, but background, sensitive strains S. marcesens yielded variety other serotypes. Carriage on hands hospital personnel implicated as mode within apparently transmission between hospitals. Antibiotic resistance largely episomally mediated, gentamicin, cephalothin, colistin not transferable.