Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies.
作者： Susbin Raj Wagle , Daniel Walker , Bozica Kovacevic , Ahmed Gedawy , Momir Mikov
DOI: 10.1038/S41598-020-64355-Z
关键词:
摘要: Probucol (PB) is a drug that exhibits significant hydrophobicity and substantial intra inter individual variability in oral absorption, with miniature bioavailability complex three compartmental pharmacokinetic modelling due to its high lipid affinity, low stability octanol water partition coefficient. Multiple attempts formulate PB have not produced satisfactory stable matrices, drug-release profile or rheological flow properties for optimum manufacturing conditions, positive none toxic biological effects. Lithocholic acid (LCA) has recently shown optimise formulation cell uptake of drugs. Hence, the aim this study was design new delivery system, using LCA, examine morphology, rheology, stability, cellular formulated LCA sodium alginate (PB-LCA-SA) various microencapsulation methodologies, best investigated vitro ex vivo. Using our Ionic Gelation Vibrational Jet technology, PB-LCA-SA microcapsules showed good significantly enhanced viability, respiration, reduced inflammation suggesting potential applications
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