Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells.

摘要: Treatment of K562 cells with the iron chelator desferrioxamine results in gradual increase total cell receptors for transferrin. Receptor number rises 2.5-4.5-fold over 24 h and remains at elevated level if is continuously present. Preincubation ferric chloride abolishes effect. The drug has no effect on 7-h half-life receptor. increased can be accounted by a specific rate receptor biosynthesis which reaches 3-4 times that seen untreated 6 after addition chelator. Isolation mRNA from treated reveals that, 8 presence desferrioxamine, there 3-fold translation transferrin cells. Total protein synthesis not changed under these conditions.