Impaired endothelial function with essential hypertension assessed by ultrasonography

摘要: The objective of this investigation was to evaluate the role hypertension in endothelial function, changes which are known be an early event atherosclerosis. We assessed function 13 subjects with normal blood pressure and essential who had never been treated for or hyperlipidemia no history smoking coronary cerebrovascular disease. B-mode ultrasonography used measure diameter brachial artery. Endothelium-dependent dilatation as change artery during reactive hyperemia. Endothelium-independent evoked, a control, by sublingual administration isosorbide dinitrate. Despite similar ages lipid glucose levels study groups, endothelium-dependent less patients (13.1% +/- 1.6%) than (18.5% 1.9%) (p < 0.05), whereas dinitrate-induced were similar. Systolic diastolic significantly correlated vasodilatation (r = -0.57 r -0.53, respectively) but not These results suggest that dysfunction exists precedes overt atherosclerotic