Conservative treatment and therapeutic test for endometriosis by androgens.

摘要: F ROM observations beginning in 1942,l we can state that androgen will not cure “external” endometriosis, exerts relatively little regressive effect upon hard infiltrates or fused masses as compared to cystic endometriomas, and, apart from the menopausal period, has but temporary action. Also, it may induce arrhenomimetic symptoms, which are always objectionable, possibly serious and permanent,* but, except heavy prolonged dosage, inevitable be mild. Notwithstanding above, aside relation both negative positive values. Unlike estrogen, is neither experimentally3 nor clinically fibromatogenic carcinomatogenic,3al 4 rather antigenie these respects, particularly versus inception of mammary cancer.5 It value spasmodic dysmenorrhea mastalgia, less premenstrual tension6 “functional uterine bleeding,‘” although comparable estrogen*’ 8 for latter condition. Androgen also exhibits a “tonic” approaching euphoria notably at menopause, when other favorable action prominent.a* lo In reactivate disease after menopause,llT I2 according two our cases, cause regression ovaries associated with peri-oophoritis excessive bleeding. Although been used acute pelvic inflammatory suppress menstruation, have seen residues, therefore suggest last diagnostic possibilities. The values androgen, rapid reduction pain, tenderness, swelling grossly ovarian described 19 brief case reports under diagnostic, therapeutic, preoperative, postoperative headings, including larger number early nodular cul-de-sac endometriosis minor symptoms. Contrary original intention, only inconclusive haphazard endometrial biopsies vaginal smears were obtained no hormonal assays13v I4 so nothing new presented etiology biologic androgen. However, rapidity suggests direct antagonism addition known urinary gonado. tropic hormone excretion, indicated previous reports.‘1 I5 We had experience sterol desoxycorticosterone acetate, conclusive progestin, each should theoretically