Electrocyclic Ring Closure of the Enols of Vinyl Quinones. A2H-Chromene Synthesis
作者： Kathlyn A. Parker , Thomas L. Mindt
DOI: 10.1021/OL0167199
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摘要: Thermolysis of enolizable vinyl quinones in polar, aprotic media provides 2H-chromenes. Experimental evidence supports a two-step mechanism which enolization is followed by thermal 6π-electrocyclic reaction an intermediate quinone methide. Application this method led to the total synthesis reputed structure Ageratum juvenile hormone. When are products Stille coupling, chromene annulation product obtained directly.
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