Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

Steven K. Dower, Cytokines, virokines and the evolution of immunity Nature Immunology. ,vol. 1, pp. 367- 368 ,(2000) , 10.1038/80799

Nancy A. Dower, Stacey L. Stang, Drell A. Bottorff, Julius O. Ebinu, Peter Dickie, Hanne L. Ostergaard, James C. Stone, RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nature Immunology. ,vol. 1, pp. 317- 321 ,(2000) , 10.1038/79766

Naama Barkai, Stanislas Leibler, Circadian clocks limited by noise Nature. ,vol. 403, pp. 267- 268 ,(2000) , 10.1038/35002258

P Gideon, J John, M Frech, A Lautwein, R Clark, J E Scheffler, A Wittinghofer, MUTATIONAL AND KINETIC ANALYSES OF THE GTPASE-ACTIVATING PROTEIN (GAP)-P21 INTERACTION - THE C-TERMINAL DOMAIN OF GAP IS NOT SUFFICIENT FOR FULL ACTIVITY Molecular and Cellular Biology. ,vol. 12, pp. 2050- 2056 ,(1992) , 10.1128/MCB.12.5.2050

M. J. O. Wakelam, M. M. Harnett, P. Reid, M.-C. Fleming, A. Wise, C.-A. Courtney, J. J. Gilbert, A. Stewart, C. G. Jackson, Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation. Journal of Immunology. ,vol. 156, pp. 2054- 2061 ,(1996)

J Imboden, M Newton, A Weiss, B Manger, R Shields, Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. Journal of Immunology. ,vol. 138, pp. 2169- 2176 ,(1987)

Julius O. Ebinu, Stacey L. Stang, Christine Teixeira, Drell A. Bottorff, Jonathan Hooton, Peter M. Blumberg, Michele Barry, R. Chris Bleakley, Hanne L. Ostergaard, James C. Stone, RasGRP links T-cell receptor signaling to Ras. Blood. ,vol. 95, pp. 3199- 3203 ,(2000) , 10.1182/BLOOD.V95.10.3199

Sarah E Henrickson, Thorsten R Mempel, Irina B Mazo, Bai Liu, Maxim N Artyomov, Huan Zheng, Antonio Peixoto, Michael P Flynn, Balimkiz Senman, Tobias Junt, Hing C Wong, Arup K Chakraborty, Ulrich H von Andrian, T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation Nature Immunology. ,vol. 9, pp. 282- 291 ,(2008) , 10.1038/NI1559

H. H. McAdams, A. Arkin, Stochastic mechanisms in gene expression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 814- 819 ,(1997) , 10.1073/PNAS.94.3.814

J. Elf, M. Ehrenberg, Spontaneous separation of bi-stable biochemical systems into spatial domains of opposite phases Systems Biology. ,vol. 1, pp. 230- 236 ,(2004) , 10.1049/SB:20045021