HLA and longevity
作者： J. Proust , R. Moulias , F. Fumeron , F. Bekkhoucha , M. Busson
DOI: 10.1111/J.1399-0039.1982.TB01436.X
关键词:
摘要: One hundred fifty-five healthy nonagenarians, 45 men and 100 women, all French Caucasians, were phenotyped for alleles of the A, B, C, DR loci HLA complex. The observed antigen frequencies compared to those a control series 133 males 179 females whose ages ranged from 10 50 years. When comparing total young elderly series, no significant differences with respect distribution or heterozygosity at any loci. taking sex difference into account, however, an excess Cw1 was found in group (p less than 0.001) Cw7 0.001). Of particular significance fact that belonged this instance phenotypic combination (and most probably corresponding haplotype) A1/Cw7/B8/DR3 which significantly increased male nonagenarians These results support hypothesis certain haplotypes are associated survival advantage.
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