Targeting inflammation in metabolic syndrome

摘要: The metabolic syndrome (MetS) is comprised of a cluster closely related risk factors, including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high-density lipoprotein cholesterol; all which increase the for development type 2 diabetes cardiovascular disease. A chronic state inflammation appears to be central mechanism underlying pathophysiology resistance MetS. In this review, we summarize recent research has provided insight into mechanisms by underlies individual components MetS hyperglycemia dyslipidemia, hypertension. On basis these mechanisms, therapeutic modalities target in its components. Current can modulate have direct anti-inflammatory effect. Lifestyle modifications exercise, weight loss, diets fruits, vegetables, fiber, whole grains, low-fat dairy saturated fat glucose are recommended as first line therapy. Mediterranean dietary approaches stop hypertension especially beneficial been shown prevent Moreover, diet associated with reductions total mortality. Omega-3 fatty acids peroxisome proliferator–activated receptor α agonists lower levels triglyceride; their role targeting reviewed. Angiotensin-converting enzyme inhibitors, angiotensin blockers, aldosterone blockers comprise pharmacologic therapies but also other aspects inflammation. Statin drugs many inflammatory pathways involved