Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosin.
作者： N C Joyce , M F Haire , G E Palade
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摘要: In these studies we have compared the relative amounts and isoforms of tropomyosin in capillary postcapillary venule pericytes, endothelial cells, vascular smooth muscle cells four rat microvascular beds: heart, diaphragm, pancreas, intestinal mucosa. The results, obtained by situ immunoperoxidase localization, indicate that (a) is present pericytes relatively high concentration; (b) content appears to be somewhat lower than but higher endothelia other vessel-associated cells; (c) unlike nonmuscle contain detectable levels immunologically related isoform. These results our previous findings concerning presence a cyclic GMP-dependent protein kinase (Joyce, N., P. DeCamilli, J. Boyles, 1984, Microvasc. Res. 28:206-219) demonstrate significant at least two proteins important for contraction regulation. Taken together, evidence suggests are contractile elements possibly involved, as latter, regulation blood flow through microvasculature.
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