Method for refining sugammadex sodium

作者: Wang Bingyong

DOI:

关键词:

摘要: A method for refining sugammadex sodium is provided: adding a protective agent to crude sodium, and obtaining pure by performing recrystallization under the protection of inert gas. Among them, one or mixture two more, in any ratio, selected from group consisting mercaptoethanol, thioglycolate, thioglycolate ester, mercaptopropionate, mercaptopropionate glutathione, cysteine, cystamine, dithioerythritol, dithiothreitol, trisubstituted organophosphorus compound, salt compound. The simple operation, high product purity, good economy, more suitable industrial production.

参考文章(11)
Ponnaiah Ravi, Praveenkumar Neela, Uppala Manikya Rao, Batthini Ravindrabhai Guruswamy, Sribhashyam Ravikanth, An improved process for preparation of sugammadex sodium ,(2013)
Ravi Kanth Sribhashyam, Guruswamy Batthini, Prasad Chlnv, Naresh Dongari, Ravi Ponnaiah, Valsan Nandkumar Mecherill, Improved process for preparation of sugammadex ,(2011)
Björn Dr. Degel, Markus Dr. Arendt, Martin Dr. Welter, Gerhard Dr. Stumm, Thomas Dr. Schwarz, Sorbent comprising on its surface a cationic or protonizable aliphatic residue for the purification of organic molecules ,(2012)
Ronald Palin, David Jonathan Bennett, Mingqiang Zhang, 6-Mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block ,(2000)
Hai Ming Wang, Gerhard Wenz, Solubilization of Polycyclic Aromatics in Water by γ‐Cyclodextrin Derivatives Chemistry-an Asian Journal. ,vol. 6, pp. 2390- 2399 ,(2011) , 10.1002/ASIA.201100217
Julia M. Adam, D. Jonathan Bennett, Anton Bom, John K. Clark, Helen Feilden, Edward J. Hutchinson, Ronald Palin, Alan Prosser, David C. Rees, Georgina M. Rosair, Donald Stevenson, Gary J. Tarver, Ming-Qiang Zhang, Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. Journal of Medicinal Chemistry. ,vol. 45, pp. 1806- 1816 ,(2002) , 10.1021/JM011107F
Yan Chen, Xiangwei Liu, Huijuan Jia, Sugammadex preparation and purification method ,(2016)
Zhao Ziwei, Xiao Zhiyang, Zhao Fuqiang, Yang Jialiang, Long Yuanqiang, Preparation method for sugammadex and intermediates thereof ,(2016)
Chen Yin, Zhang Guisen, Yang Xiangping, Li Ziqiang, Wang Shengqing, Method for purifying sugammadex sodium ,(2016)
Yan Chen, Xiangwei Liu, HuiJuan Jia, Process for preparation and purification of Sugammades sodium ,(2018)