Molecular Profiling of Human Hepatocellular Carcinoma

作者: Anuradha Budhu , Xin Wei Wang

DOI: 10.1007/978-3-319-34214-6_5

关键词:

摘要: Numerous studies of human gene function have been launched since the sequencing genome. Global molecular profiling hepatocellular carcinoma (HCC) are providing a comprehensive view expression changes that occur during carcinogenic process and uncovering promising biomarkers with clinical potential. In this chapter, an overview recent genomic HCC is provided along summation mechanistic, diagnostic, prognostic significance these findings. Emerging concepts associated also addressed. Current studies, conducted on multiple platforms, powerful tools, which useful clues to begin unravel mechanisms biology improve outcome.

参考文章(218)
Yoon Jin Hwang, Younghee Kim, Young Kwan Sung, Sanguk Im, Won Young Tak, Jung-Chul Kim, Moon Kyu Kim, Eun Jung Chung, Mohammad Farooq, Hyung Soo Han, Yang Il Kim, Gene expression profile analysis in human hepatocellular carcinoma by cDNA microarray. Molecules and Cells. ,vol. 14, pp. 382- 387 ,(2002)
Tim F Greten, Nisar P Malek, Michael P Manns, Petra Huber, Sebastian Schmidt, The diagnosis and treatment of hepatocellular carcinoma. Deutsches Arzteblatt International. ,vol. 111, pp. 101- 106 ,(2014) , 10.3238/ARZTEBL.2014.0101
Juling Ji, Tobias Eggert, Anuradha Budhu, Marshonna Forgues, Atsushi Takai, Hien Dang, Qinghai Ye, Ju‐Seog Lee, Ji Hoon Kim, Tim F Greten, Xin Wei Wang, None, Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma Hepatology. ,vol. 62, pp. 481- 495 ,(2015) , 10.1002/HEP.27822
Sean P. Cleary, William R. Jeck, Xiaobei Zhao, Kui Chen, Sara R. Selitsky, Gleb L. Savich, Ting-Xu Tan, Michael C. Wu, Gad Getz, Michael S. Lawrence, Joel S. Parker, Jinyu Li, Scott Powers, Hyeja Kim, Sandra Fischer, Maha Guindi, Anand Ghanekar, Derek Y. Chiang, Identification of driver genes in hepatocellular carcinoma by exome sequencing Hepatology. ,vol. 58, pp. 1693- 1702 ,(2013) , 10.1002/HEP.26540
Kornelius Schulze, Christin Gasch, Katharina Staufer, Björn Nashan, Ansgar W. Lohse, Klaus Pantel, Sabine Riethdorf, Henning Wege, Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma. International Journal of Cancer. ,vol. 133, pp. 2165- 2171 ,(2013) , 10.1002/IJC.28230
Yuan-Shuai Huang, Yong Dai, Xiao-Fang Yu, Shi-Yun Bao, Yi-Bing Yin, Min Tang, Cheng-Xiao Hu, Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis. Journal of Gastroenterology and Hepatology. ,vol. 23, pp. 87- 94 ,(2007) , 10.1111/J.1440-1746.2007.05223.X
Augusto Villanueva, Anna Portela, Sergi Sayols, Carlo Battiston, Yujin Hoshida, Jesús Méndez-González, Sandrine Imbeaud, Eric Letouzé, Virginia Hernandez-Gea, Helena Cornella, Roser Pinyol, Manel Solé, Josep Fuster, Jessica Zucman-Rossi, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet, , DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma Hepatology. ,vol. 61, pp. 1945- 1956 ,(2015) , 10.1002/HEP.27732
David Y Zhang, Nicolas Goossens, Jinsheng Guo, Ming-Chao Tsai, Hsin-I Chou, Civan Altunkaynak, Angelo Sangiovanni, Massimo Iavarone, Massomo Colombo, Masahiro Kobayashi, Hiromitsu Kumada, Augusto Villanueva, Josep M Llovet, Yujin Hoshida, Scott L Friedman, A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection Gut. ,vol. 65, pp. 1754- 1764 ,(2016) , 10.1136/GUTJNL-2015-309655
A. Pang, I.O. Ng, S.T. Fan, Y.L. Kwong, Clinicopathologic significance of genetic alterations in hepatocellular carcinoma. Cancer Genetics and Cytogenetics. ,vol. 146, pp. 8- 15 ,(2003) , 10.1016/S0165-4608(03)00103-1