A randomised controlled trial of the immunogenicity and safety of a formaldehyde-inactivated Coxiella burnetii vaccine in 8-week-old goats.

摘要: Abstract Coxiella burnetii causes Q fever in individuals exposed to infected ruminants. Vaccination 3-4-month-old goats, has been reported result significantly greater reduction C. shedding compared goats vaccinated one month before breeding, the most commonly used strategy of controlling on intensively-managed herds. It is possible that an even number animals could be achieved if vaccination were administered shortly after protection from colostrum antibodies wanes and become susceptible infection with burnetii. This study aimed evaluate immunogenicity safety a formaldehyde-inactivated phase 1 vaccine 8-week-old goats. Two injections, four weeks apart, elicited specific IgM IgG responses all (n = 6), while no detected two control groups (n = 12). Swelling at site inoculation was observed 10/11 placebo-treated but receded 3 weeks. Weight change rectal temperatures also comparable between The data indicated this suitable for immunising although further trials determine level against challenge are required.