Progressive neurological dysfunction during latent HIV infection.

摘要: OBJECTIVE--To determine whether the delayed conduction through spinal cord and peripheral nerves seen in patients with AIDS is related to infection HIV or presence of an immunodeficient state. DESIGN--Two year prospective follow up study electrophysiological measurements subjects positive for antibody but without AIDS. SETTING--HIV screening clinic clinical departments a university hospital Copenhagen, Denmark. SUBJECTS--Twelve homosexual men who had not developed RESULTS--Eight latencies were measured: from ankle T12, wrist C7, T12 cerebral cortex, C7 gluteal crease (tibial nerve), Erb9s point (median C7. Spinal increased all at by mean 4.2% (SE 0.9%) except one 5.5% (1.0%). The time was 32.0% (5.0%) whereas that median tibial only 5.6% (1.0%) 2.2% (2.2%) respectively. CONCLUSIONS--A mild slowly progressive neuropathy axonal type more severe myelopathy myeloradiculopathy occur concomitantly early infection, possibly as result direct neurotropic action HIV.