A Human Kidney cDNA Which Induces a Cell Surface Protein Epitope Recognized by a Monoclonal Antibody against Galactosylceramide

摘要: Antibodies against the myelin glycolipid galactosylceramide are widely used to study distribution and function of this molecule. However, anti-galactosylceramide antibodies not monospecific have been shown recognize epitopes carried only by other glycolipids, but also proteins. Using expression cloning we identified a human kidney cDNA which induces cell-surface protein recognized monoclonal antibody R-mab. These findings further support idea that cross-reactive proteins may mediate some biological effects anti antibodies.