Quality of life after palliative treatment for oesophageal carcinoma -- a prospective comparison between stent placement and single dose brachytherapy.

摘要: Metal stent placement and single dose brachytherapy are commonly used treatment modalities for the palliation of inoperable oesophageal carcinoma. We investigated generic disease-specific health-related quality life (HRQoL) after these palliative treatments. Patients with dysphagia from carcinoma were randomised to a covered Ultraflex (n = 108) or (12 Gy) 101). obtained longitudinal data on (dysphagia score, European Organisation Research Treatment Cancer (EORTC) OES-23, visual analogue pain scale) (EORTC Quality Life-Core 30 Questionnaire (QLQ-C30), Euroqol (EQ)-5D) HRQoL at monthly home visits by specially-trained research nurse. compared between two treatments analysed changes in during follow-up. Dysphagia improved more rapidly than brachytherapy, but long-term relief was better brachytherapy. For HRQoL, there an overall significant difference favour four out five functional scales EORTC QLQ-C30 (role, emotional, cognitive social) (P < 0.05). Generic deteriorated over time all QLQ C-30 EQ-5D, particular physical role functioning (on average -23 -24 100 points scale 0.5 years follow-up). This decline pronounced group. Major improvements seen eating contrast other this measure, which remained almost stable Reported levels chest abdominal follow-up both groups, general increased minor extent. The effects favourably those cancer. Future studies care cancer should least include scales, since responsive measuring patients' well-being scales.