Synergistic Activity of Gamma-Linolenic Acid and Cytotoxic Drugs against Pancreatic Adenocarcinoma Cell Lines
作者： PA Whitehouse , AJ Cooper , CD Johnson , None
DOI: 10.1159/000073651
关键词:
摘要: Background: γ-Linolenic acid (GLA) is growth inhibitory both in vitro and vivo, at doses non-toxic to non-cancer cells. Chemotherapeutic agents have limited activity pancreati
core.ac.uk
karger.com 
sci-hub.se 参考文章(42)
B. J. M. Braakhuis, G. J. Peters, C. M. Kuiper, G. Veerman, V. W. T. Ruiz Van Haperen, A. M. Bergman, Interaction between cisplatin and gemcitabine in vitro and in vivo. Seminars in Oncology. ,vol. 22, pp. 72- 79 ,(1995)
Stephen J. Wigmore, Kenneth C. H. Fearon, Jean P. Maingay, James A. Ross, Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. Clinical Science. ,vol. 92, pp. 215- 221 ,(1997) , 10.1042/CS0920215
Ralf-Marco Liehr, George Melnykovych, Travis E. Solomon, Growth effects of regulatory peptides on human pancreatic cancer lines PANC-1 and MIA PaCa-2 Gastroenterology. ,vol. 98, pp. 1666- 1674 ,(1990) , 10.1016/0016-5085(90)91105-F
H A Burris, M J Moore, J Andersen, M R Green, M L Rothenberg, M R Modiano, M C Cripps, R K Portenoy, A M Storniolo, P Tarassoff, R Nelson, F A Dorr, C D Stephens, D D Von Hoff, Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. Journal of Clinical Oncology. ,vol. 15, pp. 2403- 2413 ,(1997) , 10.1200/JCO.1997.15.6.2403
D. Ravichandran, A. Cooper, C.D. Johnson, Effect of 1-γlinolenyl-3-eicosapentaenoyl propane diol on the growth of human pancreatic carcinoma in vitro and in vivo European Journal of Cancer. ,vol. 36, pp. 423- 427 ,(2000) , 10.1016/S0959-8049(99)00268-3
C.F. van der Merwe, J. Booyens, H.F. Joubert, C.A. van der Merwe, The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial Prostaglandins Leukotrienes and Essential Fatty Acids. ,vol. 40, pp. 199- 202 ,(1990) , 10.1016/0952-3278(90)90098-6
M Kornmann, U Butzer, J Blatter, HG Beger, KH Link, Pre-clinical evaluation of the activity of gemcitabine as a basis for regional chemotherapy of pancreatic and colorectal cancer Ejso. ,vol. 26, pp. 583- 587 ,(2000) , 10.1053/EJSO.2000.0951
Karsten Ridwelski, Frank Meyer, Current options for palliative treatment in patients with pancreatic cancer. Digestive Diseases. ,vol. 19, pp. 63- 75 ,(2001) , 10.1159/000050655
A. T. HØSTMARK, E. LYSTAD, Growth inhibition of human hepatoma cells (HepG2) by polyunsaturated fatty acids. Protection by albumin and vitamin E Acta Physiologica Scandinavica. ,vol. 144, pp. 83- 88 ,(1992) , 10.1111/J.1748-1716.1992.TB09270.X
Xin Shi, Shengli Liu, Jörg Kleeff, Helmut Friess, Markus W. Büchler, Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. Oncology. ,vol. 62, pp. 354- 362 ,(2002) , 10.1159/000065068