Treatment Status Predicts Differential Prefrontal Cortical Responses to Alcohol and Natural Reinforcer Cues among Alcohol Dependent Individuals
作者： Scott C. Bunce , Kurtulus Izzetoglu , Meltem Izzetoglu , Hasan Ayaz , Kambiz Pourrezaei
DOI: 10.1007/978-3-642-31561-9_20
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摘要: This study used functional near-infrared spectroscopy (fNIRs) to test the hypothesis that non-treatment seeking alcohol-dependent participants (NTSA) would show greater response in dorsolateral prefrontal cortex (DLPFC) alcohol cues than recovering alcoholics (RA; sober 90-180 days) or social drinkers. Opposite predictions were made for responses natural reward cues. NTSA (n=4), RA (n=6), and drinkers (n=4) exposed while being monitored with fNIRs. Results confirmed enhanced among vs. right middle frontal gyrus. The opposite effect (RA>NTSA) was found Neural negatively correlated DLPFC. Real-time craving ratings positively neural Differential drug suggest a psychological mechanism related treatment status may modulate cue
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