The effect of chronic nitric oxide synthase inhibition on blood pressure and heart rate in unrestrained pregnant rats as recorded by radiotelemetry

摘要: Abstract Objectives: The objective of this study was to determine the effect chronic nitric oxide synthase inhibition on heart rate and intravascular blood pressure in unrestrained pregnant rats as recorded by radiotelemetry. Study Design: Heart systolic diastolic pressures were monitored beginning with day 6 pregnancy until 1 week post partum a radiotelemetric device. On 10 osmotic minipumps implanted subcutaneously loaded continuously deliver N G -nitro-L -arginine methyl ester (50 mg/d per rat, n=6 animals) or vehicle (control group, animals). Results: Blood animals treated significantly increased compared that control group decreased immediately after blockade. then trended downward gestation progressed, difference between became nonsignificant 17. Refractoriness blockade especially evident pressure. Systolic, diastolic, mean again higher than those delivery remained so despite lower experiment ended postpartum 6. Conclusions: Radiotelemetry can be used monitor intra-arterial unstressed, animals. Chronic does not cause sustained hypertension throughout pregnancy. Nitric appear only factor responsible for vascular changes factors refractoriness are specific disappear delivery. (Am J Obstet Gynecol 1999;181:159-64.)