Weight loss improves fasting flow-mediated vasodilation in adults: a meta-analysis of intervention studies.

摘要: Abstract Background Obesity is associated with vascular endothelial dysfunction. Effects of weight loss on function are however not clear. Therefore, we performed a meta-analysis to quantify effects flow-mediated vasodilation (FMD) the brachial artery, measurement function. Methods Studies experimental (RCTs) and quasi-experimental designs published before June 2014 were identified by systematic search. Changes in FMD defined as difference between measurements after study. For RCTs, changes corrected for those no-weight control group. Summary estimates weighted mean differences (WMDs) 95% confidence intervals (CIs) calculated using random-effect meta-analyses. The impact subject characteristics, type weight-loss treatment, dietary composition was also investigated. Results Four RCTs involving 265 subjects included. Weight increased vs. 3.29% (95% CI: 0.98–5.59%; P  = 0.005; loss: 8.6 kg). A total 1517 participated 33 studies 49 relevant study arms. It estimated that each 10 kg decrease body fasting 1.11% 0.47–1.76%;  = 0.001). more pronounced when participants had coexisting obesity-related morbidities. Also, may be larger received low-fat diets or weight-reduction regimens including exercise therapy medication. Conclusion significantly improves adults, which risk marker cardiovascular disease. depend composition.