Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double-blind, randomized, vehicle-controlled study.

摘要: A double-blind, randomized, vehicle-controlled, parallel-group trial was performed to compare the efficacy and tolerability of tazarotene 0.1% gel vehicle in 31 patients with fingernail psoriasis. Patients were randomized receive or gel, which they applied each evening for up 24 weeks 2 target fingernails, one under occlusion unoccluded. The treatment resulted a significantly greater reduction onycholysis occluded nails (P < = .05 at 4 12) nonoccluded week 24). Tazarotene also pitting There no other significant between-group differences pitting, subungual hyperkeratosis, leukonychia, nail plate crumbling/loss, splinter hemorrhage, growth rate. well tolerated only 5 21 tazarotene-treated reporting treatment-related adverse event (all mild moderate). In conclusion, can reduce (in nails) is