Comparison of coupling subsites and inhibition effects of piperidine alkaloids and aminoketones on plant amine oxidases.
作者： Pavel Peč , Ivo Frébort
DOI: 10.3109/14756369109030397
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摘要: AbstractIn the present work we compare binding subsites of inhibitors from a series alkaloids and aminoketones on pea sainfoin diamine oridase (EC 1.4.3.6; DAO) by graphical method. As standard competitive have chosen oxoanalogs substrates, namely. 1.4-diamino-2-butanone 1.5-diamino-3-pentanone, which were compared with (+)-sedamine. (-)-norallosedamine, (-)-nonedamhe, L-lobeline, cinchonine aromatic analogs aliphatic such as l-amino-3-phenyl-3-propanone l-amino-3-phenyl-2-propanone. In case DAO all compete for same 1,4-diamino-2-butanone 1,5-diamino-3-pentanone (α = ∞). enzyme they are bound to otheir interaction constants (0 <α < 1) point positive attraction between these two types inhibitors. With DAO, is into subsite 1,4-diamino-2-butanone. Cinchonine l-amino-3-phenyl-3-prop...
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