Poly (ADP-Ribose) Synthetase as a Novel Therapeutic Target for Circulatory Shock

摘要: Poly (ADP-ribose) synthetase (PARS), also known as poly(ADP-ribose) polymerase (PARP), is an abundant nuclear enzyme present throughout the phylogenetic spectrum [1]. The precise physiologic roles of PARS remain undefined; its traditional role a DNA-repair has been questioned by recent studies [2]. appears to play diverse roles, participating in DNA repair [3,4], chromatin relaxation [5], cell differentiation [6], replication [7], transcriptional regulation [8], control cycle [9], p53 expression and apoptosis [10], transformation [11]. In last decade, novel concept emerged that circulatory shock, various other pathophysiological conditions, plays crucial generation inflammatory response organ injury. Here we summarize evidence favoring this new for shock evaluate therapeutic opportunities afforded inhibition.