An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets
作者： T.Y Fan , S.L Wei , W.W Yan , D.B Chen , J Li
DOI: 10.1016/S0168-3659(01)00508-9
关键词:
摘要: To develop new pulsatile release tablets, which can suppress drug in stomach and the rapidly after a predetermined lag time of about 3 h intestine, use tablets with ethylcellulose/Eudragit L as coating film cross-linked polyvinylpyrrolidone core was investigated. The diltiazem hydrochloride (DIL) model investigated vitro. (t10) prolonged an increase level, whereas rate almost constant, irrespective level. water-uptake study electron microscope photographs suggested mechanism drug. Pulsatile containing 60 mg DIL 4.4 vitro were administrated to eight volunteers. mean plasma concentration curves showed 4.9 (tlag), 8.0 maximum (tmax) 3.1 between tmax tlag (t(psi)) vivo. Relative bioavailability 1.05 for compared conventional tablets.
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