Upregulations of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats
作者： Kiyomi Hori , Noriyuki Ozaki , Shigeyuki Suzuki , Yasuo Sugiura
DOI: 10.1016/J.PAIN.2010.03.005
关键词:
摘要: The role of ion channels expressed in sensory neurons on mechanical and thermal hyperalgesia was examined a rat model cisplatin-induced peripheral neuropathy. rats were injected with 3mg/kg cisplatin intraperitoneally once per week for five consecutive weeks. von Frey test, pin-prick test plantar performed to examine any noxious sensitivity the skin. Randall-Selitto gastrocnemius muscle (GM) measurement grip forces quantify hyperalgesia. Coordination/motor assessed by Rota-rod testing. Expressions TRPV1, TRPV2, P2X(3) ASIC3 dorsal root ganglion (DRG) afferent innervating GM. Effects antagonists against either or ASICs behavioral responses evaluated. Mechanical allodynia both skin observed cisplatin-treated animals. P2X(3), increased all DRG neurons. In addition, expressions also DRGs. Antagonists P2X(3,2/3) showed suppressive effect induced administration. Upregulation may play important roles cisplatin. Furthermore, treatment connection upregulation ASIC3.
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