Response to Pneumococcal Vaccine in the Elderly: No Enhancement by Indomethacin

作者: William P. Lafferty , Daniel S. Selinger , Gerald Schiffman , James S. Goodwin

DOI: 10.3109/08923978109026429

关键词:

摘要: We investigated whether indomethacin administration would augment the antibody response to pneumococcal vaccine in a group of healthy elderly individuals. There was no significant difference mean increases levels 12 polysaccharide types between 20 subjects who received 25 mg q.i.d. for five days after immunization and control not receiving indomethacin. In addition, there correlation within this 40 individuals three measures immune function (absolute lymphocyte count, delayed hypersensitivity testing, phytohemagglutinin) vaccine.

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