Classification of membrane transporters.

摘要: In summation, classification of membrane transporters is a challenging issue. One must consider not only their primary structure, but one also ponder function, topology, evolutionary origins, substrate specificity, and structural architecture. It known to what extent convergence divergence played role in the progression transporters. A major question remaining be resolved whether common ancestry indeed implies similar folding into molecular architecture, as commonly assumed for soluble proteins. Most transporter gene families share structure highly conserved among members same family. Transporter often include diverse functions terms specificity translocation mechanism. However, sequence similarities different are limited. difficult establish relationships between distant because recurrent TMD– loop with restricted amino acid content. For better understanding these polytopic proteins, we determine how diversity has evolved, structures fold mature transport protein. Much remains learned about biology