Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway.

摘要: Environmental chemicals have been proposed to impact endocrine or retinoid pathways, causing developmental abnormalities in humans and other vertebrates. Presented evidence shows that exposure of zebrafish embryos sunlight-induced photolytic products the pesticide methoprene results defects head, heart, pectoral fins, somites, spinal motor optic nerve axons. Exposed are phenocopies you-type mutants and, as mutant sonic-you, show underexpression signaling protein sonic hedgehog. Reduced expression hedgehog is also displayed treated with retinoic acid synthesis inhibitor citral. This study identifies citral-related compounds embryonic disruptors potential environmental concern.